Tumor Necrosis Factor Alpha in Amyotrophic Lateral Sclerosis: Friend or Foe?
نویسندگان
چکیده
منابع مشابه
Anti-tumor Necrosis Factor Therapy for Crohn Disease: Friend or Foe to the Surgeon?
Anti-tumor necrosis factor (anti-TNF) therapy is an effective therapeutic strategy for the induction and maintenance of remission in patients with Crohn disease (CD). Initially, anti-TNF therapy was employed as a last resort for patients with severe CD, but it has now been recently accepted as a conventional option regardless of induction or maintenance of remission. Patients with CD are well k...
متن کاملIs tumor necrosis factor-α friend or foe for chronic heart failure?
Although detrimental effects of tumor necrosis factor-α (TNF-α) have been reported in failing myocardium, clinical trials using TNF-α antagonists did not show the benefit of TNF-α inhibition in patients with chronic heart failure (CHF). The double-edged effects of TNF-α/Toll-like receptors (TLRs)-related proinflammatory cytokines and downstream signal transduction, nuclear factor (NF)-κB activa...
متن کاملAMPK in cancer: Tumor friend or foe?
AMP-activated protein kinase (AMPK) is a downstream target of the tumor suppressor and serine/threonine kinase, LKB1. LKB1 phosphorylates conserved threonine residues in the activation loops not only of AMPK but also of several AMPK-related kinases, activating all of them. AMPK (but not the AMPK-related kinases) is switched on in an LKB1-dependent manner by energy stress, and acts to conserve A...
متن کاملEvaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis
Background The pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), is a pathogenic element for a number of disorders. Previous studies have reported that the -1031 T/C and -238 G/A polymorphisms in the promoter region of the TNF-α gene are important factors in reproductive-related disorders. One of the most common gynecological diseases of women during the reproductive years is endo...
متن کاملAntioxidants - friend or foe?
Particularly in the field of advertising and in popular scientific journals, antioxidants such as β-carotene (from carrots) or lycopenes (from tomatoes) and the vitamins C and E are one-sidedly portrayed as substances capable of offering protection against cancer or ageing because they diminish or prevent the effects of free radicals. However, free radicals should by nomeans be considered as be...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cells
سال: 2021
ISSN: 2073-4409
DOI: 10.3390/cells10030518